While stealth is preferred, combat is inevitable. Master Parry-Stagger-Attack combos to break enemy defenses. Use Smoke Bombs for crowd control, allowing you to escape or perform multiple assassinations. Prioritize enemies with firearms first. Learn to identify enemy types; Brutes are slow but powerful, while Agile enemies are quick. Use environmental hazards like explosive barrels to your advantage. Don't be afraid to disengage and re-stealth if overwhelmed; retreat is a valid tactic.
