Don't stick to a single loadout throughout the entire campaign. Adapt your weapons and equipment to the mission at hand. For missions with tight corridors and close-quarters combat, an SMG or shotgun paired with a Synaptic Rig (Equalizer Payload) can be devastating. For open-area engagements or defensive stands, an Assault Rifle or LMG with a Merc Rig (Reactive Armor) is more suitable. Always check the mission briefing for environmental cues and anticipated enemy types.
Experiment with different Prototype weapons. An Epic variant of your favorite weapon can significantly boost its performance. Pay attention to the perks on your Prototypes; 'Deadeye' on a sniper rifle, for example, makes headshots even more rewarding. utilize your secondary weapon; a pistol can be a lifesaver when your primary runs dry, and a launcher is essential for C6 robots or vehicles. Always scavenge ammo from fallen enemies to ensure you never run out in a critical moment.