While not a sentient 'boss', the Black Death and other plagues are devastating events that can wipe out entire populations and cripple your dynasty. This 'environmental boss' requires proactive management. Invest in 'Disease Resistance' innovations, build hospitals (if available), and consider 'Secluding' your court when a plague is nearby. Ensure you have multiple healthy heirs to prevent a game over. The economic and demographic recovery after a plague is a significant challenge in itself.
