Don't just equip trinkets for raw stats; look for powerful synergies between trinkets and hero skills. For example, a trinket that grants 'Crit' tokens on hit pairs exceptionally well with a hero who has high multi-hit skills. A trinket that boosts 'Blight' potency is perfect for the Plague Doctor. Some trinkets have negative drawbacks; try to pair them with heroes who can mitigate those drawbacks (e.g., a speed debuff on a naturally slow hero). Always consider the region you're entering and adjust trinkets to counter prevalent damage types or enemy resistances.

Synergy Examples:
- Leper: Accuracy trinkets + damage trinkets.
- Plague Doctor: Blight potency + speed trinkets.
- Highwayman: Crit chance + Riposte damage trinkets.
- Man-at-Arms: Block chance + HP trinkets.