DC Universe Online features a diverse array of power sets, each with unique mechanics and playstyles. Here's a brief overview of some popular choices and their key abilities:

- Fire (Tank/DPS): Focuses on burning enemies and self-healing. Key abilities: Immolation, Inferno, Stoke Flames.
- Ice (Tank/DPS): Specializes in damage absorption and freezing enemies. Key abilities: Ice Armor, Winter Ward, Frost Snipe.
- Gadgets (Controller/DPS): Utilizes traps, turrets, and stealth. Key abilities: Battle Drone, Stasis Field, Stealth.
- Mental (Controller/DPS): Employs psychic attacks and crowd control. Key abilities: Mass Hysteria, Psychic Shock, Telekinetic Bolt.
- Sorcery (Healer/DPS): Summons pets and uses mystical healing. Key abilities: Summon Fury, Soul Siphon, Transmutation.
- Nature (Healer/DPS): Transforms into animal forms and uses regeneration. Key abilities: Savage Growth, Swarm, Pheromone Bloom.
- Light (Controller/DPS): Constructs hard-light objects for offense and defense. Key abilities: Light Barrier, Fan, Ram.
- Electricity (Healer/DPS): Focuses on burst healing and damage-over-time. Key abilities: Tesla Ball, Arc Lightning, Galvanize.
Each power set has a unique 'power tree' in the Skills menu (K key) where you unlock abilities and passive buffs. Experiment to find what suits your playstyle.