The EVE UI is incredibly flexible. Beyond basic window placement, consider creating multiple Overview profiles for different activities (PvE, PvP, mining, hauling). Customize your bracket settings to highlight specific targets or ignore clutter. Use hotkeys extensively for module activation, locking targets, and navigation. Experiment with the 'Compact Mode' for windows to save screen real estate. Saving and loading UI layouts can drastically improve your efficiency and reaction time in critical situations. Don't be afraid to spend time perfecting your setup.

Advanced UI Customization — EVE Online Guide