Liberty City is divided into three main islands, each with its own distinct atmosphere, gangs, and challenges. You will start your journey in Portland, a gritty industrial district. As you progress through the story, you will unlock Staunton Island, the commercial and business hub, and finally Shoreside Vale, a more suburban and affluent area. Each island presents new opportunities, new enemies, and new missions. Familiarize yourself with the layout of each island, key landmarks, and safe houses to efficiently navigate and plan your criminal endeavors.

Portland Island:
- Key Areas: Red Light District, Saint Mark's, Portland Docks, Trenton, Harwood
- Dominant Gangs: Leone Family, Triads, Diablos
- Characteristics: Industrial, working-class, many narrow streets and alleys.
Staunton Island:
- Key Areas: Fort Staunton, Aspatria, Bedford Point, Torrington, Belleville Park
- Dominant Gangs: Yakuza, Colombian Cartel, Yardies
- Characteristics: Commercial, high-rise buildings, more open roads, central park.
Shoreside Vale:
- Key Areas: Pike Creek, Wichita Gardens, Francis International Airport, Cochrane Dam
- Dominant Gangs: Colombian Cartel, Hoods
- Characteristics: Suburban, residential, airport, dam, more winding roads.
Always keep an eye on your mini-map for mission objectives, safe houses, and important pickups. Learning the fastest routes between key locations will save you valuable time during timed missions and escapes.