You'll be facing two or three thugs. The game will prompt you with melee combat controls. Use the Left Mouse Button (PC) to punch, Right Mouse Button to block, and F to kick. You can also dodge by pressing Spacebar while aiming. Focus on one enemy at a time.
Blocking is crucial to minimize damage. After blocking an attack, you often have an opening for a counter-attack. Don't let them surround you. If Roman is taking too much damage, try to draw the enemies' attention. Once all the thugs are defeated, another cutscene will play, and the mission will conclude. This mission emphasizes the importance of situational awareness and effective use of melee.