Liberty City is divided into three distinct islands, each with its own unique atmosphere, challenges, and unlockable areas. Initially, only Portland is accessible. As you progress through the main story, Staunton Island and Shoreside Vale will become available, expanding your playground significantly. Familiarizing yourself with the layout of each island and the key landmarks will greatly assist your navigation and mission planning.

The Three Islands:
- Portland: The industrial heartland of Liberty City. Home to the Leone family's operations, the Red Light District, and the docks. This is where you'll start your journey. Key landmarks include Saint Mark's Bistro, the Portland Docks, and the Lighthouse.
- Staunton Island: The commercial and financial district, featuring towering skyscrapers, upscale neighborhoods, and the city's university. This island becomes accessible after completing a significant portion of the Portland storyline. Key landmarks include the Liberty City Cathedral, the Casino, and the Liberty City University.
- Shoreside Vale: The suburban and residential area, characterized by its airport, dam, and more spread-out communities. This is the final island to unlock, typically towards the latter half of the game. Key landmarks include Francis International Airport, the Cochrane Dam, and the Cedar Grove residential area.
The in-game map, accessible via the pause menu, provides a detailed overview of the city, showing roads, safehouses, mission markers, and other points of interest. Use it frequently to plan your routes and locate objectives. Remember that bridges connecting islands will be blocked until you progress far enough in the story.