When sheer firepower is needed, heavy weapons and explosives are your best friends. These items are designed for maximum destruction, capable of taking out vehicles, large groups of enemies, or even entire buildings. They are often found in specific locations, purchased from Ammu-Nation, or acquired during missions.

- Grenade: Standard throwable explosive.
- Molotov Cocktail: Incendiary device, creates an area of fire.
- Tear Gas: Non-lethal, disorients enemies.
- Remote Explosives (Satchel Charges): Can be placed and detonated remotely, great for ambushes.
- Rocket Launcher: Fires powerful rockets, ideal for destroying vehicles and helicopters.
- Heat-Seeking Rocket Launcher: Locks onto air vehicles, making them easy targets.
- Minigun: Extremely high rate of fire, shreds anything in its path.
- Flamethrower: Sets enemies and vehicles ablaze.
Heavy weapons and explosives are often mission-critical or useful for clearing out heavily fortified areas. The Minigun is a true force of nature, capable of sustained, devastating damage. Rocket Launchers are essential for dealing with airborne threats or armored vehicles. Always be mindful of splash damage when using explosives, as CJ can be caught in the blast. These weapons are generally more expensive and have limited ammunition, so use them strategically for maximum impact.