The Nightclub is a chaotic environment with loud music and flashing lights, which can sometimes obscure enemy positions. This is where you'll first encounter 'Fat Guys'. When facing a Fat Guy, your best bet is a firearm, preferably a shotgun. If you only have melee, you'll need to hit them multiple times or stun them with a thrown weapon before closing in. They are slow, so you can often kite them. The 'Carl' mask, which starts you with a drill, can be very effective against them. Use the dance floor and various obstacles for cover. check the bathrooms and side rooms for hidden enemies and potential weapons.
