While not a story boss, Brainiac appears as a formidable opponent in certain S.T.A.R. Labs missions. He utilizes powerful projectiles, teleports, and a character trait that summons drones. The key to defeating him is to stay aggressive and close the distance, as his close-range options are weaker. Punish his teleport attempts and block his projectile barrages.

- Key Strategy: Aggressive rushdown, close the distance.
- Avoid: Giving him space to zone with projectiles and drones.
- Punish: His teleport recovery and slow heavy attacks.
- Character Trait: Drones can be destroyed with attacks.