Movement in League of Legends is primarily controlled by your mouse. Right-clicking on the ground will move your champion to that location. Right-clicking on an enemy unit or structure will initiate an attack. Abilities are cast using the Q, W, E, and R keys. Summoner spells are typically bound to D and F. Items can be activated using keys 1-7. The spacebar centers the camera on your champion, and Y locks/unlocks the camera. Mastering these basic controls is fundamental to effective gameplay. Experiment with different keybindings in the settings to find what's most comfortable for you.
League of Legends
Basic Controls and Movement — League of Legends Guide
Master League of Legends basic controls and movement. Learn to move your champion with right-clicks, cast abilities using QWER, and center your camera.