Chapter 2 introduces Sirens, which have high evasion, and Flesh Golems, which are tanky. You'll also encounter the River tile, which can be placed parallel to other tiles to enhance their effects (e.g., Forest becomes Thicket, providing more attack speed). The Arsenal tile, once unlocked, provides an additional equipment slot, a massive power boost.
Focus on building strong tile synergies. Placing a Vampire Mansion next to a Village can create a Ransacked Village, which spawns Ghouls but provides better healing. Experiment with different combinations to find what works best for your current class and build.