Defensive and utility items are crucial for protecting your lead, maintaining your combo, and gaining an advantage. Knowing when to use these items can save a race. Key items include:

- Mushroom: Provides a short speed boost. Excellent for cutting corners, escaping hazards, or maintaining a combo.
- Triple Mushrooms: Three individual mushrooms for multiple boosts.
- Super Star: Grants temporary invincibility and a speed boost. Makes you immune to all attacks and allows you to ram through opponents.
- Bullet Bill: Transforms you into a Bullet Bill, automatically steering you forward at high speed and making you invincible.
- Heart: Creates a shield that blocks one incoming item. Can be held behind you for protection.
- Bubble: Makes you float forward automatically, protecting you from some attacks but also making you slower.
- Coin: Adds coins to your total and contributes to your combo. Can be useful for reaching score thresholds.
Holding a defensive item like a Banana or Green Shell behind you can block incoming Red Shells, a vital technique for staying in the lead.