Metal Gear Solid 2 features a diverse cast of antagonists, each with unique personalities and combat styles. Understanding their motivations and weaknesses is key to defeating them. From the enigmatic Revolver Ocelot to the deadly Dead Cell members, each boss fight requires a different strategy. Pay attention to their dialogue for clues.

- Revolver Ocelot: Master of revolvers, cunning strategist.
- Olga Gurlukovich: Skilled sniper, leader of mercenaries.
- Dead Cell: Fortune, Fatman, Vamp. Each with unique abilities.
- Solidus Snake: Former President, powerful combatant.