Chapter 2 delves deeper into the narrative, introducing new threats and expanding your operational capabilities. You'll encounter more challenging enemy types and environments. This chapter often features missions with multiple objectives or larger-scale infiltrations. Focus on upgrading your gear, developing new weapons, and utilizing your buddies effectively to overcome the increased difficulty. The story begins to unravel more complex themes.

While the open-world environments offer more freedom, the survival-focused resource management in this chapter echoes the primitive medicinal systems found in Metal Gear Solid 3: Snake Eater.