While stealth is paramount, combat is sometimes unavoidable. Having the right weapon for the situation can make all the difference. Ammunition is limited, so use it wisely.

- Handgun: Your starting weapon. Low damage, but useful for taking out single guards quietly. Ammunition is relatively common.
- Submachine Gun: A rapid-fire weapon with higher damage than the Handgun. Good for clearing rooms or dealing with multiple enemies, but consumes ammo quickly.
- Grenades: Explosive devices that can clear groups of enemies or destroy certain obstacles. Limited supply, so use them strategically.
- Rocket Launcher: The most powerful weapon in the game, essential for boss battles and destroying Metal Gear. Ammunition is very scarce.
- Plastic Explosives (C4): Used for destroying specific targets, including Metal Gear itself, and opening certain walls. Limited use.
- Shotgun: A powerful close-range weapon, effective against multiple enemies in a cone. Ammunition is less common than for the Handgun.
Always keep an eye on your ammo count. Running out of ammunition in a critical situation can be fatal. Prioritize picking up ammo for your most powerful weapons.