While the game allows for some non-linearity in exploration, there's an optimal path for acquiring upgrades that will make your journey smoother. Generally, mobility upgrades should be prioritized, followed by offensive and defensive enhancements.

- Spider Ball: Essential for early exploration and reaching new areas.
- Spring Ball: Further enhances Morph Ball mobility.
- Space Jump: Game-changing for vertical navigation and avoiding hazards.
- Screw Attack: Provides invincibility and powerful offense, crucial for later Metroids.
- Missile Expansions: Continuously collect these as they are vital for Metroid battles.
- Energy Tanks: Prioritize these if you're taking too much damage.
- Power Bomb Expansions: Useful for clearing paths and specific boss strategies.
Always be on the lookout for these items. A well-equipped Samus is an unstoppable Samus.