Movement in Path of Exile is primarily done by left-clicking on the ground. Your character will automatically move to that location. Interact with objects, NPCs, and enemies by left-clicking them. Skills are assigned to your mouse buttons (right-click, middle-click) and keyboard hotkeys (Q, W, E, R, T). You can customize these bindings in the options menu. Holding 'Shift' while attacking will make your character attack in place, preventing accidental movement.
