The Persona 3 cast brings a diverse set of skills and roles to your party, often excelling in specific areas. Their unique Main Personas provide a solid foundation for various builds.

- Yukari Takeba (Io): A dedicated Wind magic user and primary healer. Her Mediarama and Garudyne skills are invaluable. Build her with Sub-Personas that boost her healing power, provide additional elemental coverage (e.g., Ice or Electric), or offer defensive buffs.
- Junpei Iori (Hermes): A physical attacker with Fire magic. His Agilao and Blade of Fury skills make him a versatile damage dealer. Equip him with Sub-Personas that boost physical attack, provide critical hit chance, or cover his weakness to Ice.
- Akihiko Sanada (Polydeuces): A powerful Electric magic user and physical attacker, also capable of debuffing. His Zionga and Fist of Fury are strong. Build him with Sub-Personas that enhance Electric damage, provide additional physical skills, or offer defensive buffs.
- Mitsuru Kirijo (Penthesilea): A strong Ice magic user and support character. Her Mabufudyne and Spirit Drain are excellent. Equip her with Sub-Personas that boost Ice damage, provide healing, or offer status ailment infliction.
- Aigis (Palladion): A tanky physical attacker with support capabilities. Her Orgia Mode and physical skills make her a frontline powerhouse. Build her with Sub-Personas that boost HP, physical defense, or provide healing/buffs.
- Ken Amada (Nemesis): A Light magic user and spear wielder, also capable of healing. His Hamaon and Diarahan are useful. Equip him with Sub-Personas that boost Light damage, provide additional healing, or cover his weakness to Dark.
- Shinjiro Aragaki (Castor): A heavy physical attacker with Dark magic. His Herculean Strike and Mudoon are potent. Build him with Sub-Personas that boost physical attack, provide critical hit chance, or offer defensive buffs.