The Persona 4 cast offers a balanced mix of elemental damage, physical prowess, and versatile support options, making them adaptable to many party compositions.

- Yu Narukami (Izanagi): A versatile character, often excelling in Electric magic and physical attacks. His Ziodyne and Cross Slash are strong. Build him with Sub-Personas that boost Electric damage, provide critical physical skills, or offer healing/support.
- Yosuke Hanamura (Jiraiya): A fast Wind magic user and physical attacker. His Garudyne and Brave Blade are excellent. Equip him with Sub-Personas that boost Wind damage, provide speed buffs, or offer status ailment infliction.
- Chie Satonaka (Tomoe): A dedicated physical attacker with Ice magic. Her God's Hand and Bufula are powerful. Build her with Sub-Personas that boost physical attack, provide critical hit chance, or cover her weakness to Fire.
- Yukiko Amagi (Konohana Sakuya): A powerful Fire magic user and primary healer. Her Agidyne and Mediarahan are invaluable. Equip her with Sub-Personas that boost Fire damage, provide additional healing, or offer defensive buffs.
- Kanji Tatsumi (Take-Mikazuchi): A heavy physical attacker with Electric magic. His Ziodyne and Primal Force are devastating. Build him with Sub-Personas that boost physical attack, provide critical hit chance, or offer defensive buffs.
- Rise Kujikawa (Himiko): A dedicated support character, providing invaluable buffs, debuffs, and healing. Her abilities are unique and crucial for difficult fights. Equip her with Sub-Personas that boost her healing, provide additional support skills, or offer defensive buffs.
- Naoto Shirogane (Sukuna-Hikona): A versatile Light/Dark magic user and critical hit specialist. Her Hamaon, Mudoon, and Megidolaon are potent. Build her with Sub-Personas that boost Light/Dark damage, provide critical hit chance, or offer status ailment infliction.