Mastering combat in Persona Q2 goes beyond hitting weaknesses. Here are some advanced strategies:

- Boost Management: Don't just use Boosts for free attacks. Sometimes, saving a Boosted character for a crucial healing spell or a powerful Unison Attack can be more effective. Also, remember that a Boosted character's next action is guaranteed to hit, making them ideal for high-risk, high-reward skills.
- F.O.E. Engagement: While often best avoided, engaging F.O.E.s strategically can be beneficial. Some F.O.E.s drop rare materials or provide significant EXP. If you decide to fight one, ensure your party is fully prepared, and try to ambush them for a preemptive strike.
- Status Ailment Synergy: Status ailments are incredibly powerful. Inflicting Panic can make enemies attack each other, while Dizzy can prevent them from acting. Combine status ailments with skills that deal extra damage to afflicted foes for massive damage.
- Unison Attack Timing: Unison Attacks are powerful, but their activation conditions can be specific. Plan your turns to ensure the required characters are available and have enough SP. Use them to burst down tough enemies or clear groups of minions.
- Front/Back Row Management: Place your squishier magic users and healers in the back row to reduce incoming physical damage. Your tanks and physical attackers should be in the front row to maximize their damage output.