While both characters have fixed weapon sets, optimizing your upgrades and inventory management is crucial. For Leon, prioritize the Shotgun Stock and Long Barrel for increased damage and capacity. For Claire, the High-Capacity Mag for the JMB Hp3 and the Shoulder Stock for the MQ 11 are excellent choices. Always aim to carry at least one defensive item (knife or grenade) and a mix of healing items. Don't hoard all your powerful ammo; use it strategically on tougher enemies and bosses to conserve resources.
