Scattered throughout the game are various safes and lockers that contain valuable items like weapon upgrades, ammunition, and healing supplies. The combinations for these are often found on nearby notes, files, or environmental clues. For example, the Downtown Safe combination is usually found in the Drugstore Owner's Journal. Always read every document you pick up, as they often contain vital information. Unlocking these provides a significant advantage, especially on higher difficulties where resources are scarce. Don't miss out on these easy-to-miss upgrades.

While Resident Evil 3 utilizes fixed codes found in notes, Resident Evil: Revelations 2 employs a different lockpicking mechanic where players must find sweet spots using a flashlight.
While Resident Evil 3 utilizes fixed codes found in files, Resident Evil Village expanded this mechanic by integrating environmental puzzles and physics-based clues into its lock combinations.