The first encounter with Wesker is a test of timing and teamwork. He is incredibly fast and difficult to hit. The strategy involves stunning him with a flash grenade (after he's taken some damage) or by shooting him as he charges. Once stunned, Chris can grab him from behind while Sheva injects him with a serum. This is a multi-stage fight, often involving quick-time events (QTEs). In the second part, in the missile silo, use the environment to your advantage, shooting the glowing missile to stun him.

Strategy:
- Weakness: Vulnerable to flash grenades when damaged.
- Tactic: Flash, then Chris grabs, Sheva injects.
- Missile Silo: Shoot glowing missile to stun.
- Recommended Weapons: Flash Grenades, Magnum, Shotgun.