Resource management is key in Resident Evil 5. Conserve ammo by aiming for headshots or weak points, and utilize melee attacks when enemies are stunned. Always check every corner for hidden items and treasures. Your partner, Sheva, is invaluable; learn to issue commands effectively (Attack, Cover, Follow) to maximize her utility. Don't be afraid to restart a section if you're struggling, and remember that co-op play significantly eases the difficulty.

Essential Tips:
- Headshots & Weak Points: Maximize damage and conserve ammo.
- Melee Attacks: Follow up stunned enemies for powerful, ammo-free damage.
- Explore Thoroughly: Find hidden items, ammo, and treasures.
- Partner Commands: Use 'Attack' and 'Cover' strategically for Sheva.
- Resource Management: Don't waste healing items or precious ammunition.
- Co-op Play: Highly recommended for a more enjoyable and manageable experience.