Resident Evil 5
Resident Evil 5

Uroboros Wesker (Chapter 6-3)

Resident Evil 5 Uroboros Wesker boss guide: expose his back weak point with teamwork and unleash heavy firepower.

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The final boss battle takes place in a volcanic environment. Wesker transforms into a massive Uroboros creature. His weak point is the large, glowing orange sac on his back. Chris needs to distract him while Sheva uses the environment (a rock) to create a path to his weak point. Once exposed, unleash all your heavy firepower. The Rocket Launcher (infinite ammo if unlocked) is highly effective here. Be mindful of the lava and his powerful attacks.

Uroboros Wesker (Chapter 6-3) - Resident Evil 5 screenshot
Uroboros Wesker (Chapter 6-3)

Strategy:

  • Weak Point: Large orange sac on his back.
  • Tactic: Chris distracts, Sheva creates path, both attack weak point.
  • Environment: Use the rock to expose his back.
  • Recommended Weapons: Rocket Launcher, Magnum, Grenade Launcher.