Carla Radames, in her mutated form, is a massive, amorphous blob of C-Virus biomass. This fight is less about direct damage and more about environmental manipulation. You'll need to activate various mechanisms in the environment (e.g., giant fans, pressure valves) to expose her core or create openings for attack. Use your crossbow's explosive bolts for additional damage when she's vulnerable. Avoid her sweeping attacks and the smaller C-Virus creatures she spawns. The final phase involves a timed sequence to destroy her completely before she overwhelms you.
While the battle against Carla emphasizes environmental hazards over raw firepower, it mirrors the persistent, adaptive threat posed by the relentless titular pursuer in Resident Evil 3: Nemesis.