Derek C. Simmons mutates into several grotesque forms throughout Leon's campaign. His first form is a quadrupedal beast. Aim for the glowing weak points on his body. When he charges, dodge to the side. His second form is a massive, multi-limbed creature. Focus fire on the exposed eyes and mouth. The final form is a giant, insect-like creature. You'll need to use the environment, such as the train's turrets, to deal significant damage. Always prioritize dodging his powerful attacks and conserving ammo for his vulnerable phases.
