Your team is deployed to a heavily damaged section of Raccoon City, likely a downtown area or industrial zone, where the Nemesis has been sighted. The area will be a chaotic mix of infected, UBCS, and possibly US Spec Ops, all fighting each other. Your primary focus is to navigate this warzone and track the Nemesis.
The Nemesis will be actively hunting S.T.A.R.S. members, so you might encounter it engaging other forces. Use these opportunities to your advantage, letting other factions soften it up before you engage. The environment will offer plenty of cover, but also many choke points where the Nemesis can corner you. Follow the objective marker, which will lead you to a large, open arena-like area where the final confrontation will take place.