A core mechanic of Resident Evil: Revelations 2 is the ability to switch between two characters at almost any time using the Triangle/Y button. Each pair – Claire and Moira, and Barry and Natalia – offers unique abilities that are crucial for progression and combat. Mastering their combined strengths is essential for survival.

Claire & Moira:
- Claire: The primary combatant. She wields firearms and is proficient in direct combat. Her role is to eliminate threats and protect Moira.
- Moira: A support character. She cannot use firearms but is equipped with a powerful flashlight that can stun enemies, reveal hidden items, and blind certain foes. She also carries a crowbar for melee attacks against downed enemies and for opening specific doors or containers. Her flashlight is invaluable for navigating dark areas and exposing weak points.
Barry & Natalia:
- Barry: The heavy hitter. Barry carries powerful firearms, including shotguns and magnums, making him excellent for dealing high damage to tough enemies.
- Natalia: A unique support character with a supernatural ability to sense enemies through walls and identify their weak points. She can also point out hidden items and throw bricks to stun or distract enemies. Her ability to see the invisible Glasps is absolutely critical for Barry's survival in later chapters.
Strategic character switching is vital. For example, as Claire, stun an enemy with Moira's flashlight, then switch back to Claire for a headshot. As Barry, use Natalia to pinpoint an enemy's weak spot before engaging. Remember that your partner will generally follow you and provide some basic support, but direct control allows for much more effective teamwork.