Beyond firearms, sub-weapons and melee attacks provide crucial utility and damage options. These tools are often overlooked but can be game-changers in tight situations or for conserving precious ammunition.

- Moira's Flashlight: Essential for stunning enemies, revealing hidden items, and blinding certain foes. It has a charge that replenishes over time. Use it frequently to create openings for Claire.
- Moira's Crowbar: Her primary melee weapon. Effective for finishing off downed enemies, conserving ammo, and opening specific boarded-up doors or containers.
- Natalia's Bricks: Natalia can pick up and throw bricks to stun or distract enemies. This is invaluable for crowd control or creating an escape route for Barry.
- Knives: Both Claire and Barry carry knives. These are weak but have infinite uses. Best used for breaking crates, barrels, or finishing off very weak, downed enemies to save ammo.
- Explosive Bottles: Crafted from Gunpowder and Empty Bottles. Standard grenades that deal area-of-effect damage.
- Firebombs: Crafted from Alcohol and Cloth. Incendiary grenades that deal fire damage over time and can stun enemies. Effective against groups.
- Decoy Bottles: Crafted from Gunpowder, Empty Bottle, and Cloth. Attract enemies to their landing spot, allowing you to bypass them or set up an ambush.
- Smoke Bottles: Crafted from Gunpowder, Empty Bottle, and Alcohol. Create a smoke screen, obscuring enemy vision and allowing for stealth or escape.
Mastering the use of these sub-weapons and melee options will significantly improve your combat efficiency and resource management throughout the game.