Resident Evil: Revelations 2 offers several unlockables and a robust New Game+ system that encourages multiple playthroughs. Completing the game on different difficulties or achieving specific objectives will grant you access to new content.

- New Game+: After completing the main campaign, you can start a New Game+ playthrough. This allows you to carry over all your acquired weapons, weapon parts, upgrades, and skills from your previous save. This makes subsequent playthroughs on higher difficulties or for collecting missed items much more manageable.
- Unlockable Difficulties: Completing the game on Normal unlocks Hard. Completing Hard unlocks Very Hard. Completing Very Hard unlocks Countdown Mode and Invisible Mode.
- Countdown Mode: A challenging mode where you have a strict time limit to complete each section. Killing enemies adds time to the clock.
- Invisible Mode: All enemies are invisible, requiring reliance on sound and partner abilities.
- Bonus Episodes: Two additional episodes, 'The Struggle' (Moira) and 'Little Miss' (Natalia), are available as DLC or included in certain editions. These provide additional story content and unique gameplay mechanics.
- Costumes: Completing certain objectives or finding specific collectibles can unlock alternate costumes for characters, usable in both campaign and Raid Mode.
- Raid Mode Characters: Progressing through the campaign and completing Raid Mode missions unlocks additional playable characters for Raid Mode, each with unique skills.
The game is designed for replayability, so don't hesitate to dive back in after your first completion to experience everything it has to offer.