Beyond basic aiming and firing, several advanced combat techniques can significantly improve your survival rate:

- Perfect Dodge: Timing your dodge perfectly just before an enemy attack lands will grant you a brief period of invincibility and often a counter-attack opportunity. Mastering this is crucial for conserving health and ammo, especially against faster enemies like Fenrir or Rachael.
- Melee Follow-ups: After stunning an Ooze with a few shots (usually to the head), quickly close the distance and perform a melee attack. This often knocks them down, saving ammo and dealing significant damage.
- Environmental Hazards: Look for explosive barrels or other volatile objects in the environment. Shooting these when enemies are nearby can clear groups or deal massive damage to stronger foes.
- Weapon Switching: Quickly switch between weapons to adapt to different threats. For example, use a shotgun for close-range Ooze, then switch to a rifle for a distant Scagdead.
- Grenade Usage: Don't hoard grenades. Use them strategically for crowd control, stunning bosses, or clearing tight corridors. Shock Grenades are particularly effective against aquatic Ooze.
Practice these techniques in Raid Mode or by replaying earlier story missions to hone your skills. The perfect dodge, in particular, can make even the toughest encounters manageable.