Upon completing the main story, you unlock New Game+ and higher difficulty settings. New Game+ allows you to restart the story with all your previously acquired weapons, custom parts, and character upgrades (for the character you played as). This is invaluable for tackling the harder difficulties.
Difficulty Settings:
- Casual: Easiest difficulty, generous ammo and health drops.
- Normal: Standard experience, balanced challenge.
- Infernal: Harder difficulty, enemies are tougher, resources are scarcer.
- Hell: The ultimate challenge. Enemies are extremely powerful, resources are minimal, and even basic Ooze can be deadly. Requires perfect execution and mastery of all game mechanics.
For your first playthrough, Normal is recommended. For subsequent runs, especially for achievement hunting, New Game+ on Infernal or Hell difficulty provides a significant challenge. Use your upgraded arsenal and knowledge of enemy placements to your advantage. Remember that enemy patterns and locations can sometimes change slightly on higher difficulties.