Beyond weapons, several crucial items can turn the tide of battle. These are typically found as pickups or are part of a character's starting loadout.

- Hand Grenade: Explodes after a short fuse, dealing area-of-effect damage. Excellent for clearing groups of standard enemies or damaging mini-bosses.
- Flash Grenade: Blinds and stuns most enemies in its radius, leaving them vulnerable to melee attacks. Invaluable for crowd control and setting up combo chains. Also effective against Garradors.
- Incendiary Grenade: Explodes and sets enemies on fire, dealing damage over time. Good for softening up tougher enemies or clearing groups.
- Green Herb: Restores a small amount of health. Essential for survival. Always pick these up when your health is low.
- First Aid Spray: Fully restores your health. Very rare and should be saved for critical situations.
Strategic use of grenades is paramount for high scores. Flash Grenades, in particular, are excellent for maintaining combos by allowing you to chain multiple melee attacks. Always be aware of your surroundings for item pickups, especially green herbs when your health is low.
Compare usable items (grenades & healing) inResident Evil 3: Nemesis