Key items are essential for progression, unlocking new areas, and solving the mansion's intricate puzzles. Many require careful examination or combination with other items.

Mansion Keys:
- Armor Key, Sword Key, Shield Key, Helmet Key: These are the primary keys that unlock most doors in the mansion. They are consumed upon use.
Small Keys (Jill Only):
- Description: Used to open locked drawers. Jill's Lockpick can open many of these without consuming a Small Key.
Emblems & Medallions:
- Description: Often used to open secret passages or activate mechanisms. Examples include the Death Mask, Stone & Metal Object, various Crests.
- Usage: Typically placed into specific slots or statues.
Musical Score:
- Description: A sheet of music.
- Usage: Used in the piano puzzle in the Dining Room to reveal a hidden passage.
Battery:
- Description: Powers certain devices.
- Usage: Often used to power an elevator or a gate mechanism.
Fuel Canteen & Lighter:
- Description: Used to burn zombie corpses.
- Usage: Combine Fuel Canteen with Lighter to create a 'Flamethrower' for burning. Chris starts with a Lighter. Jill must find one.
Always examine new key items in your inventory; their descriptions often contain clues for their use. Don't be afraid to backtrack if you find an item but don't immediately know its purpose.
Compare key items & puzzles inResident Evil 2 (Remake)