NETRICSA
Not an item you pick up, but your personal computer assistant. NETRICSA provides mission objectives, enemy information, and lore details. Pay attention to her messages, especially when new enemy types are introduced, as she often provides valuable tactical advice. Access her database from the pause menu for detailed enemy profiles.

C4 Explosives
Used for specific environmental objectives, such as destroying obstacles or opening new paths. These are typically provided at the exact moment they are needed and are not part of your regular inventory. Follow mission prompts to deploy them.
Goggles / Night Vision
In some darker sections of the game, you might acquire night vision goggles or a similar device. These are usually activated automatically or with a specific keybind (check your controls menu). They are essential for navigating poorly lit areas and spotting enemies in the dark. Their usage is context-specific and not a permanent inventory item.
General Strategy: While Serious Sam 3 doesn't have a complex inventory system for key items, understanding NETRICSA's role and being aware of context-sensitive gadgets like C4 or night vision is important for progression. Always read NETRICSA's updates for crucial information.