Sledgehammer
Your trusty melee weapon. Infinite ammo, instant kill on weaker enemies (Headless Kamikazes, Gnaar) with a direct hit. Useful for conserving ammo or when surrounded. Can also destroy environmental objects. Acquisition: Starting weapon.
Pistol
A reliable sidearm with unlimited ammo. Good for picking off distant, weak enemies or finishing off weakened foes. Headshots are effective against Gnaar. Acquisition: Starting weapon.
Assault Rifle (XM214-A Minigun)
Rapid-fire weapon with decent damage. Excellent for mid-range engagements and clearing out groups of smaller enemies. Uses Rifle Ammo. Acquisition: Early in 'Summer in Cairo'.
Pump-Action Shotgun
Devastating at close range. Ideal for clearing out swarms of Kleer Skeletons or dealing heavy damage to larger enemies up close. Uses Shotgun Shells. Acquisition: Early in 'Into the Spider's Nest'.
Double Shotgun
Fires two shells simultaneously for massive close-range damage. Consumes two shells per shot. Perfect for quickly dispatching tough enemies or clearing a path. Uses Shotgun Shells. Acquisition: Mid-game, often in 'The Silent Riddler' or 'No Place to Hide'.
Minigun (M29 'XL2' Minigun)
Unparalleled rate of fire and sustained damage. Melts through large enemies and entire waves. Consumes Rifle Ammo rapidly. Acquisition: Mid-game, typically in 'The Silent Riddler'.
Rocket Launcher (XPML30 Rocket Launcher)
Fires explosive rockets. Excellent for high-value targets (Biomechanoids, Arachnoids) and clearing dense groups of enemies. Be careful with splash damage at close range. Uses Rockets. Acquisition: Mid-game, often in 'The Silent Riddler' or 'The Guardian of Time'.
Grenade Launcher (MK3 Grenade Launcher)
Fires bouncing grenades that explode on impact or after a short fuse. Great for hitting enemies behind cover or clearing out tight corridors. Uses Grenades. Acquisition: Mid-to-late game, often in 'The Guardian of Time' or 'The Last Man on Earth'.
Laser Gun (Laser Cannon)
Fires a continuous beam of energy. Highly accurate and deals consistent damage. Excellent for precision targeting and sustained fire. Uses Laser Cells. Acquisition: Late game, typically in 'The Last Man on Earth'.
Cannon (SBC Cannon)
Fires massive cannonballs that pierce through multiple enemies and explode. The most powerful weapon in the game, capable of clearing entire lines of enemies. Uses Cannonballs. Acquisition: Very late game, often in 'The Last Man on Earth' or 'The Power of the Underworld'.