Effective resource management is crucial for Sam's survival, especially on higher difficulties. This isn't about character stats, but about managing your health, armor, and ammunition:

- Health & Armor: Always prioritize picking up health and armor. Small health vials restore 1 HP, large ones restore 50 HP. Small armor shards restore 1 armor, large armor vests restore 100 armor. Armor absorbs a percentage of incoming damage before health.
- Ammunition: Each weapon uses specific ammo types. Try to conserve powerful weapon ammo (Rockets, Cannonballs) for larger threats. Use your Revolver or Shotgun for weaker enemies. Don't be afraid to switch weapons frequently to avoid running out of ammo for your primary choices.
- Power-ups: Serious Damage and Invulnerability are temporary but incredibly powerful. Save them for the toughest encounters or boss fights. Knowing when to deploy these can be the difference between victory and defeat.
A well-managed inventory of health, armor, and ammo ensures Sam can withstand the relentless onslaught and keep dishing out damage. Always scan the environment for pickups after clearing an area.