Location:
Skull Cavern, all floors.
Strategy:
Serpents are fast, flying enemies that deal significant damage. They are one of the most dangerous common enemies in the game. Equip your best weapon (Galaxy Sword is ideal), high-defense boots, and a good ring combination (e.g., Iridium Band + Slime Charmer Ring or Savage Ring). Food with speed and defense buffs (e.g., Spicy Eel, Pumpkin Soup) is highly recommended. Focus on quick, decisive strikes. If overwhelmed, use bombs to clear groups or staircases to escape. They are not weak to any specific element.
Rewards:
Dragon Tooth (rare), Serpent's Fang (rare), Void Essence, Solar Essence.