Before diving into the action, you'll need to choose your hero! Shredder's Revenge features a roster of iconic characters, each with unique stats and playstyles. Understanding these differences is key to finding your perfect match.

- Donatello: High Range, Medium Power, Low Speed. Donatello excels at keeping enemies at a distance with his bo staff. His special attacks often cover a wide area.
- Leonardo: Balanced stats across the board. Leonardo is a great all-rounder, suitable for any player. His katana offers good reach and damage.
- Michelangelo: High Speed, Medium Power, Low Range. Mikey is a fast-hitter, ideal for players who enjoy quick combos and agile movement. His nunchaku are devastating up close.
- Raphael: High Power, Low Speed, Low Range. Raph is a brawler, dealing massive damage with his sai. He's best for players who like to get in close and unleash powerful attacks.
- April O'Neil: Balanced stats, similar to Leonardo but with unique special moves. April's camera and microphone attacks offer good crowd control and range.
- Master Splinter: High Power, Medium Speed, Medium Range. Splinter's staff attacks are powerful and have decent reach, making him a formidable combatant.
- Casey Jones: Unlocked after completing Story Mode. Casey is a powerhouse with high damage and unique sports equipment attacks.
Each character also has a unique 'Special' attack animation and properties. Experiment with each character to discover their strengths and weaknesses and find the one that resonates with your preferred combat style.