Shredder's Revenge shines in cooperative play, supporting up to six players. Effective teamwork can turn the tide of battle:

- Revive Teammates: If a teammate is knocked out, stand over them and press the designated button to revive them. This consumes a portion of your health but saves a life.
- Team Up Attacks: As mentioned in advanced combat, coordinate grab attacks for powerful team throws.
- Cover Each Other: In chaotic fights, ensure no one player is overwhelmed. Cover your teammates' backs, especially against ranged enemies.
- Character Synergy: Choose characters that complement each other. For example, Donatello's range can protect Raphael as he gets in close.
- Share Pizza: When a large pizza appears, wait for teammates to gather around before picking it up, as it heals everyone in the vicinity.
- Focus Fire: Against bosses or tougher enemies, coordinate your attacks to focus fire and quickly deplete their health.
- Taunt Rotation: In quieter moments, take turns taunting to quickly fill everyone's special meters.
Communication is key in co-op. Call out dangerous enemies, low health, or when you're about to use a special attack. A well-coordinated team is unstoppable!