The final boss, Alpha, is a massive, mutated Biophage requiring a combination of precise aiming, dodging, and environmental awareness. Its weak points are the glowing sacs on its body, which change location throughout the fight. Use your most powerful ranged weapons (Assault Rifle, Shotgun) and aim for these weak points. Dodge its sweeping attacks and ground slams. The arena often has environmental hazards that can be used with the GRP. This is a battle of attrition; manage your ammo and health carefully.
