Faction: Grineer
Weaknesses: Corrosive, Radiation, Slash
Drops: Equinox Warframe Component Blueprints (Day and Night forms, 8 total)
Strategy: Tyl Regor is a formidable Grineer scientist and melee combatant. The fight takes place in a series of underwater labs. He has a shield and health bar. His attacks include powerful melee combos, a sonic scream, and summoning Manic Grineer. The fight has multiple phases. In each phase, you'll fight him in a small arena. Once his health is depleted, he'll retreat, and you'll need to chase him through underwater sections. Use your Archwing to navigate these sections quickly. When he's vulnerable, focus fire on him. Manics are dangerous; deal with them quickly. His final phase involves him becoming enraged; use crowd control or high burst damage to finish him off.
Recommended Warframes: Equinox (if you have her), Inaros (high health), Nidus (survivability), Rhino (Iron Skin), Mesa (Peacemaker for burst damage).
Recommended Weapons: High damage weapons with Corrosive or Radiation. Melee weapons with high Slash damage are also very effective against him.