Disarm the Missile in Saints Row IV Guide

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Walkthrough

1
The mission begins with Kinzie reporting that Cyrus is preparing to launch a nuke at Washington and that you need to take him out.
2
You will then proceed to the mission titled "Zero Saints Thirty", which auto-starts.
3
Following this, Kinzie will comment about gerrymandering, leading to the mission "Hail to the Chief".
4
The next mission is "The Saints Wing", which also auto-starts.
5
Kinzie will then state that the perfect life is brought to you by Friendly Fryer, initiating the mission "Leave it to the Saints".
6
The mission "A Pleasant Day" will auto-start.
7
Kinzie will suggest learning how things work here, leading to the mission "Learn the Basics".
8
The mission "The Fundamentals" will auto-start.
9
Next, you will need to increase the tempo by undertaking the mission "Bending the Rules", which involves the Blazin' activity.
10
To learn how to damage the alien presence, you will undertake the tutorial mission "Hot and Cold", focusing on the Blast power.
11
Kinzie will then state the need to get back to Earth, initiating the mission "The Escape".
12
The mission "Break Out of the Simulation" will commence.
13
Kinzie will mention various ways to disrupt the simulation, leading to the mission "Breaking the Law".
14
The mission "Take Over a Store" will start, which is titled "Hack the Planet".
15
Following this, the mission "Break on Through" will begin, featuring the Platforming Rift activity.
16
You will then undergo "That Burning Sensation", a tutorial mission for Power Element Training.
17
Kinzie will express the need to acquire the AI to access other simulations, leading to the mission "Ghost in the Machine".
18
The objective is to help the AI enter the simulation, which is part of the mission "Power Up CID".
19
You will then go to a training program, specifically Prof. Genki's Mind Over Murder.
20
Kinzie will state her hatred for the AI and the need to save Matt Miller, initiating the mission "Zero Cool".
21
The mission "Break Matt Miller Out" will commence, titled "Miller-Space".
22
Next, you will retrieve Matt Miller in the mission "Matt's Back".
23
Kinzie will warn about the Zin tracking you, leading to the mission "Anomalous Readings".
24
The objective is to find the source of the readings, which is part of the mission "The Warden Stomp".
25
You will then test your mettle on the "Fight Club" activity.
26
Kinzie will caution not to get hopes up, initiating the mission "Back by Popular Demand".
27
The mission "Find Johnny Gat" will begin, titled "De Plane Boss".
28
Kinzie will state that Pierce needs help badly, initiating the mission "The Boss Goes to Washington".
29
The mission "Rescue Pierce" will commence, titled "The Saints Flow".
30
Kinzie will mention that to get back your Chief of Staff, you'll have to revisit your mutual past, leading to the mission "King of Stilwater".
31
The mission "Rescue Ben King" will begin, titled "King Me".
32
Kinzie will state that while Asha may not be pleasant, she is needed to stop Zinyak, initiating the mission "From Asha with Love".
33
The mission "Rescue Asha" will commence, titled "The Case of Mr. X".
34
Kinzie will report that something strange is happening in the simulation and you will be attacked until it's resolved, initiating the mission "Emergency Situation".
35
The mission "Something's Wrong in Steelport" will begin, titled "A Game of Clones".
36
The objective is to remove the clones from Steelport.
37
Kinzie will state that she did what you asked and you are ready to save your friend, initiating the mission "...the Very Next Day".
38
The mission "Rescue Johnny Gat" will commence, titled "Welcome Back".
39
Matt will comment that jump-kicking works in 2D sidescrollers and ask how it works here, initiating the mission "Death From Above".
40
You will learn more about "Death From Above" through the "Power Training" tutorial.
41
Shaundi will state that everything is in place and it's time to end this once and for all, initiating the mission "The Kinzie Gambit".
42
The mission "Meet the Crew to Bring Down Zinyak" will begin, titled "When a Plan Comes Together".

Tips

Pay close attention to Kinzie's dialogue for mission cues and objectives.
Utilize your superpowers effectively during combat and traversal.
The Blazin' activity and Platforming Rift are good opportunities to practice movement and combat skills.
Don't underestimate the importance of the tutorial missions for learning new abilities.