X-Men Origins: Wolverine

Mutagens:

Healing Factor

• Description: Decreases the cool down time before regeneration starts.
• Locations: 1- Weapon X facility after Wolverine loses his ability to regenerate on a platform above the necessary Power Cell. 2- At Alkali Lake after moving across the bridge where the helicopter is attacking, climb the ladder to the top of the tower. 3- Inside the room with the giant Sentinel, move the teleporter through the wall to the left.
• Usefulness: The cool down time reduction may not be significant enough to warrant using a Mutagen slot over other more important upgrades.

Inner Rage

• Description: Gain extra rage from each kill.
• Locations: 1- Weapon X facility when Wolverine has to pull the Truck out to reach a higher platform. 2- Behind Wolverine at the beginning of the Wideawake level. 3- During the Sentinel mission, found just after the hand lowers.
• Usefulness: The rage meter stays fairly full by killing enemies and destroying crates/vases, so trading this for more experience or stronger attacks might be preferable.

Samurai

• Description: Builds your combat reflexes faster.
• Locations: 1- Weapon X Facility in a room on the left while following the scientist's footprints. 2- At the beginning of the Betrayal stage, a double jump to Wolverine's right. 3- During the Sentinel Mission in the room where the power cell required is shown to Wolverine.
• Usefulness: A very good mutagen, especially if trophies are important.

Experienced

• Description: Gain extra experience from each kill.
• Locations: 1- Weapon X Facility to the right of Anna's cell. 2- Alkali Lake under Nord's position inside the building in the hall where he fires at Wolverine as Wolverine tries to reach the stairs. 3- Finding Agent Zero mission at the top of a set of broken stairs over a waterfall.
• Usefulness: This Mutagen should be equipped as faster experience gain leads to a more powerful Wolverine.

Art of War

• Description: Damage boost from Combat Reflexes.
• Locations: 1- On a ledge before meeting the Prototype in Alkali Lake. 2- Above the console Wolverine uses to freeze himself in the Raven's Explanation level. 3- Save Wraith during the Sentinel Mission.
• Usefulness: A fine mutagen, but others may seem more valuable as the boost from building reflexes themselves might be sufficient.

Unstoppable

• Description: Reduces damage taken.
• Locations: 1- To the right of the floor that falls in at the beginning of Chapter 2. 2- During the Betrayal level in the area with the moving statues that create platforms, under the stairs before the first statue. 3- During Chapter 5, in the area just after the raising floor block puzzle.
• Usefulness: If Wolverine is having problems completing missions or staying alive, this Mutagen may be the answer.

Rampage

• Description: Increases your maximum rage.
• Locations: 1- Weapon X Facility upon exiting Frost's Lab, in the room at the end of the hall on the right. 2- After moving down the bridge with the helicopter firing down at Wolverine, look to the right of the area with the enemies (Alkali Lake). 3- The Sentinel Level in the area where the hand has to be moved down a set of tracks.
• Usefulness: Rage is an important commodity in the game; more rage available means stronger offense, making this a Mutagen to consider using.

Blood Rage

• Description: When near death, Wolverine does more damage.
• Locations: 1- Upon entering the Alkali Lake complex, take the first left and the Mutagen is at the bottom of a set of stairs in the back left corner of the area with the truck where the C4 is to be planted. 2- During the Raven's Explanation mission, in the area with the cake accessed by moving the teleporter in the "freezing" area all the way to the right. 3- A room on the right after first encountering the Assassin during the 52 Pickup level.
• Usefulness: Potentially the least effective Mutagen for a normal difficult play through, as times Wolverine will be near death are minimal, and avoiding attacks through dodging, blocking, or attacking is more useful.

Vitality

• Description: Increases your maximum health.
• Locations: 1- Weapon X Facility, a room just after the area with the turret and two moving shields and just before regaining the ability to heal. 2- At Alkali Lake in the cave where the WoW Trophy is obtained. 3- During the Raven's Explanation mission, at the top of a ladder in the room with the moving platforms.
• Usefulness: While a quality Mutagen, Wolverine's health increases with each level gained and by finding Health Boosts throughout levels, so this can be left in reserve.

Savage

• Description: Gain health from damage inflicted.
• Locations: 1- At Alkali Lake, knock over the tower and use it as a bridge; once across, look to the right to see tags and a cave with this mutagen. 2- Raven's Explanation, after obtaining Trask's "Key", an elevator will take Wolverine up a level; move across the beam and ride a second lift up. 3- When outside the building during the 52 Pickup mission, Assassins will break through a window; defeat them then enter the area they exited.
• Usefulness: Wolverine's health is rarely in danger, especially with his regenerative powers, so his mutant abilities decrease the need for this Mutagen to be equipped.

Shredder

• Description: Increases damage from Fury Attacks.
• Locations: 1- At the beginning of Alkali Lake, turn around to see this mutagen. 2- At the beginning of the Raven's Explanation level. 3- During the first stage of Chapter 5, Wolverine encounters moving floor spikes; on the wall to the left is a boarded up door behind which is the Mutagen.

Combat Reflexes measure Wolverine's ability to adapt to his enemies' fighting styles and tactics. Each kill you perform raises your Combat Reflexes. Furthermore, if you learn enough from a particular enemy type, your Combat Reflexes level will increase.

Enemies that contribute to Combat Reflexes:

• Machete
• Machine gunner
• Jungle Mutants (Leviathan, Hunter, Shifter)
• Robots (Enforcer Droid, Predator Droid, Mark 1 Prototype)
• Specialized Military units (Elite Commando, Goliath, W.E.N.D.I.G.O. Prototype, Ghost, Grendadier)

This guide details all the fight moves available to Wolverine in X-Men Origins: Wolverine, categorized by attack type.