Skip to content
Part 31
The Binding of Isaac: Rebirth

Part 31

Learn about Familiars in The Binding of Isaac: Rebirth, including 1UP!, Brother Bobby, and Cube of Meat effects and appearances.

By ···10 min read·Multi-source verified
1 reading this guide  

Learn about Familiars in The Binding of Isaac: Rebirth, including 1UP!, Brother Bobby, and Cube of Meat effects and appearances.

1UP!

Walkthrough
  1. 1
    Find the 1UP! item, located at Table Position Row 2, Column 2.
  2. 2
    Upon pickup, you will receive an extra life.
  3. 3
    A green mushroom familiar will appear and follow you until you lose the extra life.
Tips
  • This item provides a massive advantage and backup, making it highly recommended.
  • 1UP! appears to be rare, so always pick it up if encountered.

Brother Bobby

Walkthrough
  1. 1
    Brother Bobby can be purchased in a Devil Room for one heart container.
  2. 2
    He acts as a familiar, shooting tears at a rate of approximately 1 shot per second.
  3. 3
    He follows your character and shoots in the same direction you do.
Tips
  • Brother Bobby adds significant extra damage in a short time.
  • His projectiles can sometimes miss enemies if they are just to the side of your own shots.
  • He is visually different from Sister Maggy but functionally similar.

Cube of Meat

Walkthrough
  1. 1
    The Cube of Meat item causes a cube of meat to float around your head.
  2. 2
    This cube damages enemies and can deflect projectiles.
  3. 3
    Collecting a second Cube of Meat in the same playthrough transforms the familiar into a Super Meat Boy head that shoots blood drops (up to three per revolution) in your firing direction.
  4. 4
    A third Cube of Meat transforms it into an invulnerable Super Meat Boy that chases enemies and deals touch damage.
  5. 5
    A fourth Cube of Meat grants the Super Meat Boy a damage and size buff.
Tips
  • Stage one protects against projectiles occasionally, saving health.
  • Stage two provides damage output similar to Brother Bobby or Sister Maggy.

100% Human-Written. AI Fact-Checked. Community Verified. Learn how AntMag verifies content