Appendix - The Final Puzzle

Master Resident Evil 9: Requiem's The Final Puzzle with our comprehensive guide. Uncover clues, decipher the GLITCH code, and input the correct sequence to succeed.

The Final Puzzle is a 20,000 CP challenge which only becomes visible after a completed playthrough. Although you can unlock some hints and a key item during your first playthrough, you can only complete the puzzle during a second playthrough. The logic is rather obscure and some of the thinking required is lateral to an absurd degree.

Playthrough 1: Gather Hints

During your first playthrough, you can gather a number of clues, most of which will make no sense.

1. Clue #1: A Toilet and the Number "8"
   When you start the game as Grace, you will find the Investigation Report file in your inventory. Open it up to view the contents and flick through the photographs. If you examine the fourth photograph, you will see one of the victims by a toilet. Note the blood swirl on the wall which traces a figure eight.
2. Clue #2: G=150000000
   When you analyse a blood sample in the Blood Lab, you may notice a sticker on the side of the Laser Microscope which reads "G=150000000".
3. Clue #3: U = 380,000
   When you reach the VIP Suite while searching for the helicopter key, pick up the hourglass on the desk and turn it upside down. Wait for the sand to drain out, allowing you to read an inscription "U = 380,000".
4. Clue #4: Collect Blood from 115 Infected
   While making your way through the Research Facility, you will find the Subject 170 Record file which records how Marie was injected with a sample extracted from the blood of 115 infected.
5. Clue #5: C = 4.2 ly
   While making your way through the Research Facility, you will find the Grace Ashcroft Blood Analysis Report file in the Private Lab area. Read it and note the mysterious entry at the bottom of the report: "C = 4.2 ly."
6. Clue #6: Just ignore A
   After defeating the Tyrant, you can reach the Basketball Court behind Gun Shop Kendo through a hole in the fence. You will find the head of a Toy Uncle figure on the ground and a basketball hoop on its side. Push the head through the hoop and then examine the hoop to receive the message "There's no time for playing around."
   Head back inside the shop and look for the rest of the Toy Uncle figure among the rubble. Inspect it to receive the message "Just ignore A."

Playthrough 1: Obtain Marie's Doll

Unlocking the doll on your first playthrough requires metaknowledge since you need to do some of the steps before you've unlocked Clue #4. If you want to solve the puzzle legitimately, you can do these steps on a second playthrough (although it might interfere with your speed run).

1. Send 115 Infected for Processing
   When you reach the Processing area in the Basement, you will see a conveyor belt dropping bodies into a pool of blood.
   The ones that matter are the zombies rather than the bodies wrapped in black plastic. Count 115 of these (which takes around ten minutes) and let a few more drop just to make sure. When this is done, turn the crank to stop the conveyor belt and drain the blood from the pool, revealing a bunch of bodies at the bottom of the pit.
   Drop down and wait for the bodies to start being "processed" by a bunch of spinning blades at the end of the pit.
   While this goes on keep your distance from the blades and stun the zombies which animate and attack. Avoid killing them - simply kneecap them to stun them. There is handgun ammo in the pit if you need it. Your goal is to send as many of the zombies through the blades as you can.
   When processing finishes, grab the final Joint Plug and use the fan next to the typewriter to leave the chamber. Grace will find herself caught in a torrent of blood which deposits her in the Collection Pool. Get out and use the lever marked "Collection & Testing" to drain the pool. When the pool is empty, you should see a message: "A ton of blood flowed out".
2. Flush the Toilet Eight Times
   When you get back to the Care Center, leave Emily in the Guard Office and make your way to the Restroom in the West Wing. Carefully flush one of the toilets a total of eight times.
3. Find Marie's Doll
   As you try to escape from the Research Centre using the Emergency Exit Route, you will reach an area where a blood-filled tank explodes, flooding the room and causing a large number of Infected to turn into Blister Heads. Run to the stairs to the south where you will find Marie's Doll.
   Place this in the Item Box when you get the chance and leave it there for the remainder of the playthrough.

Playthrough 2: Let the Sweet Pair Hear the Voice

In case you're wondering, it is not possible to complete the challenge by loading a save after completing the game once. Instead, you have to reach this point during a second playthrough.

When you manage to escape from the Basement, the Girl will have one of her hands amputated by the falling lift. Pick it up and grab Marie's Doll from the Item Box. Carry Emily to the Blood Lab and analyse the hand using the Laser Microscope.

Click on the nodes in the order shown in the screenshot above to solve the puzzle. A message will appear on the screen: "Let's play. GGC AAG AUA ACG UGU CAU".

This apparent nonsense message is, in fact, a sequence of codons for amino acids - G lycine, L ysine, I soleucine, T hreonine, C ysteine, H istidine - spelling out "GLITCH." The codons can be turned into something meaningful by applying the clues you picked up:

• A can be ignored (Clue #6): GGC GUC GUG UCU
• G = 150,000,000 (Clue #2)
• U = 380,000 (Clue #3)
• C = 4.2ly (Clue #5).

Interpret the numbers as astronomical distances:

• The Sun is 150,000,000km from the Earth
• The Moon is 380,000km distant
• The nearest star is 4.2 light years away.

This gives us a puzzle safe sequence: Sun Sun Star; Sun Moon Star; Sun Moon Sun; Moon Star Moon.

Carry Emily upstairs to the Lead Researcher's Office and input the sequence into the puzzle safe. You will hear a child's laughter and receive a congratulatory message.

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